Watch San Francisco 49ers vs Arizona Cardinals live stream in this highly anticipated NFL showdown on September 21st, 2025, at 21:25 UTC. Experience the thrill as San Francisco 49ers defend their home turf against Arizona Cardinals in this must-watch NFL event. Tune in for heart-stopping plays and intense competition in this exciting NFL game. Don't miss a second of the action - watch live and be part of the excitement! #NFL #San Francisco 49ers #Arizona Cardinals #NFLShowdown #GameDay #WatchLive